Institute for Molecular Bioscience
Cadherin cell cell adhesion and tissue organisation in health and disease
Cells are the building blopatagonia better sweater quarter zipcks of our bodies. Interactions between differenpatagonia better sweater women'st cells are important to shape patagonia shop europeour developing bodies and maintain the healthy orpatagonia discount code yoshis1ganisation of our tissues. Importantly, those interactions are disturbed in many diseases, including cancer and inflammation.
My laboratory studies one set of cell cell interactions, those that occur when cells attach to one another. We focus on the cadherpatagonia store upper west sidein family of cell cell adhesion receptors. These critically depatagonia discount code yoshis0termine the abildiscount patagonia better sweaterity of cells to recognise one another and organise into coherent tissues. The importance of these receptors is emphasised by the fact that loss of cadherin function promotes cancer progression in epithelial tissues such as the breast and colon, which are common forms of human cancers.
Cadherin dysfunction patagonia coats reviewsalso contributes to the breakdown of epithelial barriers during inflammation, notably in chronic disease of the intestine. By understanding the basic bpatagonia amazon better sweateriological mpatagonia better sweater jacket womensechanisms of cadherin mediated cell recognition, we aim to provide vital insights into the basis of development and common human diseases.
We focus on how cadherins regulate the cell cytoskeleton to control the mechanical forces they exert on one another. Our most recent work revealed that cells control the patterns of tension with which they pull opatagonia discount code yoshis2n their neighbours. By maintaining these patterns, cells are able to form epithelial tissues, the layers of cells that cover and protect organs, including skin. However, these patterns are alpatagonia discount code yoshistered when potentially cancerous cells are pushed out from epithelial tissues by surrounding cells, which can lead to cancer metastasis. This process of cellular extrusion involves many elements, including cell signals and components of the cytoskeleton, whichpatagonia everlong review 61 are regulated by cadherins to control cellular forces. All of these elements present multiple opportunities for cell cell interactions to be disturbed and promote disease.
Research in the news
16 January 2014 Stopping the spread of cancerous cells, 2ser radioView more publications by Professor Yap via Pubmed or patagonia discount code yoshis3via UQ Researchers. Cox, J. Conti, C. Yap (2010). Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens. Nature Cell Biology 12: 696 702.
