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Impact of centralising acute stroke services in English metropolitan areas on mortality and length of hospital stay

Design Analysis of difference in differences between regions with patient level data from the hospital episode statistics database linked to mortality data supplied by the Office for National Statistics.Setting Acute stroke services in Greater Manchester and London, England.Participants 258915 patients with stroke living in urban areas and admitted to hospital in January 2008 to March 2012.Interventions Hub and spoke model for acute stroke care. In London hyperacute care was provided to all patients with stroke. In Greater Manchester hyperacute care was provided to patients presenting within four hours of developing symptoms of stroke.Main outcome measures Mortality from any cause and at any place at 3, 30, and 90 days after hospital admission; length of hospital stay.Results In London there was a significant decline in risk adjusted mortality at 3, 30, and 90 days after admission. At 90 days the absolute reduction was 1.1% (95% confidence interval 2.1 to 0.1; relative reduction 5%), indicating 168 fewer deaths (95% confidence interval 19 to 316) during the 21 month period after reconfiguration in London. In both areas there was a significant decline in risk adjusted length of hospital stay: 2.0 days in Greater Manchester (95% confidence interval 2.8 to 1.2; 9%) and 1.4 days in London (2.3 to 0.5; 7%). Reductions in mortality and length of hospital stay were largely seen among patients with ischaemic stroke.Conclusions A centralised model of acute stroke care, in which hyperacute care is provided to all patients with stroke across an entire metropolitan area, can reduce mortality and length of hospital stay.IntroductionStroke is a leading cause of mortality and disability worldwide.1 Each year in England an estimated 125000 people have a stroke and 40000 of them die.2 Organised inpatient stroke unit care, which is provided by multidisciplinary teams that exclusively manage patiepatagonia adze vest reviewnts with stroke in a dedicated ward, is associated with better quality3 and reduced death and dependency.4 The Department of Health s National Stroke Strategy for England recommended major change in the system for stroke, identifying that care in a stroke unit was the single biggest factor that can improve outcomes after stroke.5 In several countries acute stroke services are being centralised as a means of improving access to organised inpatient stroke unit care. Hospitals of differing capability work together to create a centralised system of stroke care6 in which patients are taken to central specialist units rather than the nearest hospital. Research in the United States,7 8 Canada,9 the Netherlands,10 Denmark,11 and Australia12 suggests this approach can improve provision of evidence based care processes for patients with stroke for example, by increasing access to specialist care and thrombolysis. Other evidence suggests this approach is highly cost effective.13 While the improvedpatagonia black hole pack 25l review clinical outcomes associated with organised ipatagonia everlong review refrigerators1npatient stroke care are well documented, it is unknown if centralising acute stroke care to a small number of high volume specialist centres produces better clinical outcomes.14 15 In addition, the wisdom of focusing on hyperacute stroke care has been questioned.16In 2010, acute stroke services were centralised across two metropolitan areas of England (Greater Manchester, with a population of 2.68 million, and London, with 8.17 million).17 The changes in both areas entailed the selection of hospitals to become sites for specialist stroke services in multiple hub and spoke networks during the first 72 hours after stroke (fig 1).Before the changes in London, 30 hospitals provided acute stroke care. After centralisation specialist care was provided to all patients in eight designated hyperacute stroke units 24 hours a day, seven days a week, with patients being assessed immediately by specialised stroke medical teams with the capacity for immediate brain imaging and thrombolysis when appropriate. Twenty four stroke units were designated to provide acute rehabilitation services, and eight of these were attached to a hyperacute stroke unit; five hospitals were no longer patagonia buy ukto provide acute stroke services.18 Hospital selection was guided by a modelling exercise whereby potential sites were identified based on determination of need, including the travel times involved, with the intention that no Londoner would be more than a 30 minute ambulance journey away from the nearest hyperacute stroke unit.18In Greater Manchester, the original intention was also to treat all patients in hyperacute stroke units (one 24/7 comprehensive stroke centre and two primary stroke centres running 7 am 7 pm, Monday to Friday). Concerns about the number of patients being transported greater distances, difficulties with repatriation, and a view that access to specialist spatagonia everlong review refrigerators0troke centres was purely for thrombolysis, however, meant that patients presenting only within four hours of developing stroke symptoms were taken directly to a comprehensive stroke centre or primary stroke centre; all other patients were taken to one of 10 district stroke centres, which were designated to provide all aspects of post thrombolysis stroke care.19 No hospitals stopped providing stroke services entirely as a result of the centralisation process in Greater Manchester.Summary of acute stroke pathway in Greater Manchester and London before and after reconfiguration of acute stroke services. ASU=acute stroke unit, CSC=comprehensive stroke centre, PSC=primary stroke centre, DSC=district stroke centre. Before the centralisation of acute stroke services in both Greater Manchester and London, patients with suspected stroke were taken to the nearest emergency department to receive stroke care. They were then sent to either an acute stroke unit or a regular hospital ward for treatment before being discharged for community rehabilitation. After the reorganisation in Greater Manchester patients presenting within four hours of developing stroke symptoms are sent to the comprehensive stroke centre or a primary stroke centre for hyperacute care. Once stable, they are repatriated to a district stroke centre, a nursing home, or their own home for community rehabilitation. Patients presenting patagonia pullover fleece for saleoutside the four hour window are taken to the nearest DSC, receiving similar treatment to that provided before the reorganisation. After the reorganisation in London, patients presenting with stroke symptoms at any time are taken to a hyperacute stroke unit for assessment and treatment, then repatriated to a stroke Unit, to a nursing home, or to their own home for community rehabilitationFig 1 Summary of acute stroke pathway in Greater Manchester and London before and after reconfiguration of acute stroke services. ASU=acute stroke unit, CSC=comprehensive stroke centre, PSC=primary stroke centre, DSC=district stroke centre. Before the centralisation of acute stroke services in both Greater Manchester and London, patients with suspected stroke were taken to the nearest emergency department to receive stroke care. They were then sent to either an acute stroke unit or a regular hospital ward for treatment before being discharged for community rehabilitation. After the reorganisation in Greater Manchester patients presenting within four hours of developing stroke symptoms are sent to the comprehensive stroke centre or a primary stroke centre for hyperacute care. Once stable, they are repatriated to a district stroke centre, a nursing home, or their own home for community rehabilitation. Patients presenting outside the four hour window are taken to the nearest DSC, receiving similar treatment to that provided before the reorganisation. After the reorganisation in London, patients presenting with stroke symptoms at any time are taken to a hyperacute stroke unit for assessment and treatment, then repatriated to a stroke Unit, to a nursing home, or to their own home for community rehabilitationOpen in new tabWe investigated the impact of centralising acute stroke services in these two metropolitan areas on mortality and length of hospital stay. We used data for all patients in England who had a stroke during a 51 month period and controlled for trends in the rest of England during the same period and other factors that could affect outcomes. The study is part of a larger mixed methods evaluation.18MethodsDataWe obtained patient level data from the hospital episode statistics database20 for all patients in England with a primary diagnosis of stroke defined with ICD 10 (international classification of diseases, 10th revision) codes I61 (intracerebral haemorrhage), I63 (cerebral infarction), or I64 (stroke, not specified as haemorrhage or infarction) from 1 January 2008 to 31 March 2012. We excluded subarachnoid haemorrhage (ICD 10 code I60) as it is managed through a different clinical pathway.21 The data were linked to mortality data supplied by the Office for National Statistics22 by using an anonymised unique patient identifier to identify deaths from any cause and at any place (hospital or otherwise) at 3, 30, and 90 days after hospital admission. Length of stay was measured in days as the difference between date of admission and date of discharge, including same day transfers between hospitals.We started our analysis period in January 2008, after the publication of the National Stroke Strategy for the English NHS in December 2007,5 which was designed to lead to better emergency responses to stroke and acute stroke care around the country.23 Our data cover a 27 month period before the changes in Greater Manchester (which occurred in April 2010), and a 24 month period afterwards. In London they cover a 30 month period before the changes (July 2010) and a 21 month period afterwards. In both areas some hospitals began to reconfigure their services before these dates, and we control for this in our analysis using hospital and time fixed effects.Our main analysis was confined to patients living in urban areas (defined as urban less sparse using the urban/rural classification for England24: 95% of patients with stroke in Greater Manchester and London lived in these areas compared with 75% in the rest of England). We did not restrict the analysis to any type of hospital (we included hospital fixed effects to allow for hospital differences), and we did not impose a minimum number of patients to be treated at each hospital (observations in the hospital level regressions were weighted by the number of patients). Over the period of the study, patients were treated at 11 hospitals in Greater Manchester, 38 in London, and 405 in the rest of England. Data were availpatagonia everlong review refrigerators2able for 258915 admissions, of which 17650 were in Greater Manchester (9413 before reconfiguration, 8237 afterwards) and 33698 were in London (18 672 and 15026, respectively).Statistical analysisWe patagonia everlong review businessevaluated whether centralisation of acute stroke services in Greater Manchester and London had an impact on mortality and length of hospital stay using regression analysis of difference in differences between regions25 to compare the changes over time in these areas with the change over time in the rest of England. The analysis was carried out at hospital level with quarterly observations of risk adjusted mortality and length of hospital stay; the risk adjustment was conducted at the patient level on all patients in the data. The approach is consistent with Medical Research Council guidelines for using natural experiments to evaluate population health interventions,26 and a similar method was usedpatagonia everlong review refrigerators in an evaluation of the advancing quality initiative in the northwest of England.27We calculated expected risks of death at 3, 30, and 90 days after admission using patient level logistic regressions, including binary indicators for sex and age interactions (age measured in five year bands), stroke diagnosis using the first four digits of the primary ICD 10 diagnostic code (19 categories), Charlson index28 derived from secondary ICD 10 diagnostic codes, presence of 16 comorbidities included in the Charlson index, ethnic group (18 categories), deprivation quintile,29 and urban/rural classification24 (eight categories) of the area in which the patient lived (of 32482 lower layer super output apatagonia everlong review refrigerators3reas in England)patagonia everlong review 8mm. We ran the patient level regressions only on patients who had a stroke before the reorganisations in Greater Manchester and London so that the risk adjustment was not contampatagonia fly fishing new hampshireinated by the changes. The regression coefficients (derived from the logistic regressions for the period before implementation) were used to predict the probability of mortality for every patient (in periods before and after implementation). These were aggregated to create a dataset of the actual percentage of patients who died and the expected percentage by admitting hospital and quarter. We tested whether the reconfigurations had an impact on mortality using least squares regression of the actual minus expected mortality percentage (because we are modelling differences) against interaction terms between Greater Manchester and the period after reconfiguration and London and the period after reconfiguration. We included binary indicators for each of the 454 admitting hospitals (hospital fixed effects) and the 17 quarters (time fixed effects), and each observation was weighted by the number of patients treated at that hospital in that quarter. Standard errors were corrected for heteroskedasticity.We used the same approach for length of hospital stay but estpatagonia guide jacket your own bulletsimated our risk adjustment equation using a generalised linear model (GLM) with gamma family and log link to account for data skewness.30 We experimented with other GLM specifications and a log transformation but the selected model gave the best fit in terms of residual plots and Akaike s information criterion. We added binary indicators for mortality at 3, 30, and 90 days after stroke to the risk equation and used the regression coefficients to predict expected mean length of hospital stay.We undertook pre trends tests to examine whether risk adjusted mortality and length of hospital stay had a different linear trend in Greater Manchester and London compared with the rest of England before the reconfigurations. We reran the models on every quarter before the reconfigurations and included linear time trends instead of binary indicators for quarter. We added interaction terms bepatagonia guide pants templatetween Greater Manchester and the linear time trend and London and the linear time trend and tested the individual significance of the interaction terms. In every case they were non significant (P>0.05).ResultsPatients in Greater Manchester and London were slightly younger than those in the rest of England, and those in London were less likely to be white British (table 1). The proportion of intracerebral haemorrhage strokes was slightly higher in London than in the rest of England, and slightly lower in Greater Manchester. Patients in Greater Manchester and London were less likely to live in deprived areas. Unadjusted outcomes show a small decline in mortality in London compared with the rest of England, and a small decline in length of hospital stay in Greater Manchester and London. There was some evidence of difference in differences with respect to age, sex, type of stroke, and deprivation in Greater Manchester and age, ethnic group, and type of stroke in London.Table 1 Characteristics of patients before and after reconfiguration of acute stroke services in Greater Manchester and London compared with rest of England

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